BMS-986142 CAS ：1643368-58-4

BMS-986142 is a potent,selective,reversible BTK inhibitor.BMS-986142 shows BTK IC50=0.5nM;human WB IC50=90 nM.In molecule of BMS-986142,two atropisomeric centers were rotationally locked to provide a single,stable atropisomer,resulting in enhanced potency and selectivity as well as a reduction in safety liabilities.With significantly enhanced potency and selectivity, excellent in vivo properties and efficacy,and a very desirable tolerability and safety profile,BMS-986142 was advanced into clinical studies.

msds---BMS-986142